The 3D structure of APN protein has been identified, as well as its catalytic domain, allowing for targeted development of drug inhibitors to block APN’s activity. Built upon this structural knowledge, the affinity and APN-binding specificity of existing inhibitors can potentially be improved too. (2013-02-04) (20120219)
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The single camera system and algorithm can obtain the 3D geometry and depth of an object from a single 2D video. This 3D image analysis is possible as long as the distances between the scene or image and the camera are known. Since only one image-recording device is necessary, this method is simpler and less costly than other methods involving multiple camera setups. (2012-10-25) (Z03043)
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The Medical Device Opportunity Licensing Program was designed at the University of Minnesota to make it quick, easy and affordable for design and development companies to license medical device technologies at the idea or proof-of-concept stage. These technologies have a defined market need and value proposition, and require more development to fully determine their commercial feasibility. The program is designed for medical device design and development companies to add technologies to their own portfolio, or to add value through prototype development and sub-license to a larger player or startup for commercialization. (2012-11-08) (MDOL)
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Mouse cell line mimics common form of leukemia. (2012-05-02) (20100059)
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In the PEG affinity-based cell separation method, cells of interest are captured on a substrate through interactions between a cell surface biomarker and a ligand immobilized on the substrate. Cells can then be detached through the addition of a polyethylene glycol conjugate (PEG) and a heterodimer. The detachment method can be tuned for cells with specific affinity to the substrate using different sized PEGs. The substrate can be washed and reused efficiently by using solutes that competitively bind with the PEG used. (2012-07-26) (20110207)
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Statistical software that detects structural variations such as large insertions and deletions in short segments (reads) of DNA, can be used to diagnose cancer. Structural variations in short segments (reads) of DNA occur in complex diseases, such as cancer. To use these variations in diagnoses, the process of reading the DNA segments needs to be fast and inexpensive. (2013-01-10) (20110125)
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Ammonia production usually requires the formation of molecular hydrogen followed by contacting the hydrogen with molecular nitrogen over a catalyst in the Haber Bosch process for ammonia synthesis, more commonly known as simply the Haber process. This small-scale liquid anhydrous ammonia reactor allows for the production of ammonia on a distributed and as-needed basis from water vapor and air (nitrogen source). The ammonia synthesis reactor process is also able to produce ammonia at relatively low temperatures as well as atmospheric pressure. Once formed, ammonia can be used in fertilizer production and pharmaceutical production. (Z07182)
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Two vesamicol derived compounds with anti cholinergic action have been developed. These compounds can be used to modify acetylcholine activity in the synaptic cleft. They are pharmaceutically acceptable and delivery methods for the compounds have also been disclosed. The drug can be used to treat heart conditions such as arrythmias or to treat chemical agents by modulating cholinergic activity in the synaptic cleft. These compounds are less lipophillic compared to other VAChT antognists and thus can attain easy access to the brain. (2012-12-13) (97061)
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A group of small molecules have been discovered that are potent monocarboxylate transporter 1 (MCT1) inhibitors and can be used to treat hypoxic regions in tumors. MCT1 inhibitors disrupt the metabolism of the tumor cells with minimal damage to healthy cells. These molecules are potential anticancer and immunosuppressive agents. (2012-07-12) (20120012)
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An artificial cornea based on collagen and laminin that enable tissue and cell growth into a synthetic material (silica) that is known for its superior mechanical and optical as well as biocompatibility properties. (2011-12-12) (Z09049)
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The Probability of Repeated Admission (PraTM) elder health assessment survey identifies senior citizens who are at high risk of repeated hospital admissions and extensive use of health care services. The early prediction of hospital readmission risk helps those patients receive better medical attention, which will result in better health for them, and lower expenses for hospitals and senior health insurance programs. (97145)
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WK-1 is an immortalized chicken embryo fibroblast cell line. (2012-05-02) (Z04191)
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Avian clonal variant cell line improves Marek's Disease vaccine for poultry. (2012-05-02) (20120137)
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This retrovirus free cell line allows for the production of human and animal vaccines and is useful for developing vaccines which are not susceptible to retrovirus contamination. This is important because it will reduce the side effects of a vaccine developed from this cell line, and reduce the chance of vaccine recall by the FDA. (2012-05-07)(95149)
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A lantibiotic, derived from culture of Bifidobacterium longum, has natural bactericidal action against both Gram-negative and Gram-positive bacteria, including E.Coli and Salmonella. It has broad potential applications to be used as a preservative to extend shelf life or antibiotic in pharmaceutical, food and nutrition industries. (Z07178)
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Cationic peptides could be used as an alternative to treat staph infections in place of antibiotics. Bacteriostatic cationic peptide analogs block the ability of S. aureus to produce exotoxins, thus inhibiting their ability to colonize. Blocking colonization will stop the staph infection in its first stage and prevent the bacteria from becoming pathogenic. (2013-04-03) (20110209)
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A method of identifying, producing, and using as probiotics certain Bifidobacterium longum strains that inhibit gram positive and gram negative bacteria and promote healthy GI function has been developed. These strains function in the large intestine where they secrete an iron binding molecule that depletes the iron supply for unwanted iron-dependent bacteria and therefore afford protection of the large intestine from food-borne pathogens. (2012-12-18) (Z00046)
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The biocompatible material can be used as a coating for medical devices to eliminate complications such as thrombosis formation associated with body implants. (2012-20-12) (94123)
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Biodegradable epoxy elastomers based on an epoxy core structure are synthesized using “green chemistry” principles, and can be used as adhesives and coatings for biomedical devices, drug delivery, 3-D scaffolds for cell culture and tissue engineering, and elastic tissue repair and replacement. (2012-05-29) (20120103)
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A biodegradable thermoplastic has been produced from a lignin derivative that has properties similar to polystyrene. This method for creating renewable plastic uses the excess lignin generated from pulp mill operations, bioethanol production, and chemical and pharmaceutical production from plant material. It is also a renewable and biodegradable alternative to polystyrene, a material which is derived from petroleum and not biodegradable. (99187)
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Biodiesel can be produced from dry distillers grains with solubles (DDGS), leftover from corn consumed in ethanol production using this chemical process. It is an add-on system placed at the end of an existing ethanol production plant for additional revenue. The process converts corn oil extracted from the DDGS into biodiesel, and further refines the biodiesel into a useable biofuel. This biofuel is an alternative to biodiesel formed from soybeans. (Z04005)
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A three dimensional human thorax software package for impedance simulation, ZMIND, provides effective ways to determine bioelectrical current patterns and impedance measurements between various electrode combinations. The 3D human thorax simulation model is constructed based on actual human MRI scans. Up to 36 tissue types were identified and included in the model, providing high-resolution anatomical details in the heart and lung regions. The software can be used to design electrocardiographic, pacemaker, and defibrillation devices. (Z05175)
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Electronic light detectors can be used to image and/or map biological samples and for DNA chip analysis. In contrast to conventional biological imaging techniques, this method scans across the sample and detects multiple images constructed from light emitted by the biological sample. (2013-03-14) (Z02049)
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A biological pathway that produces isobutyric acid from sugar-based feedstocks has been developed using fungal and bacterial enzymes. This biological pathway is more environmentally friendly and direct than chemical synthesis. Isobutyric acid is a commodity chemical used to produce methyacrylic acid (MAA) and methyl methacrylate (MMA) which can further be processed into plastics, adhesives, ion exchange resins, and lubrication additives. (20110077)
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A biomedical sensor technique uses a giant magnetoresistor (GMR) sensor and magnetic nanoparticles to distinguish nanoparticles with different magnetic properties. The device is low cost, portable and high signal to noise compared to fluorescence techniques. This magnetic coloring allows, for example, observation of the reactions between proteins and cell membranes and a high-throughput method to sort molecules and cells. (2012-08-02) (20100020)
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Plastic Polyhydroxyalkanoate (PHA) microstructures can be formed in bacterial hosts. These materials may be applied in orthopedic devices, orthopedic implants, and other implantable medical devices. The biopolymers are synthesized in bacteria through use of a polymerase enzyme within the organisms. The microbes intake a variety of renewable feedstocks and the produced polymers within the cells can later be extracted from the organisms. (99107)
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This device is a polymer-based, self-centering, bioresorbable occlusion device for congenital cardiovascular defects. These defects include atrial septal defects, ventricular septal defects, patent ductus arteriosii, patent foramen ovale, and arterial punctures. Current methods for treating these problems include metallic parts that cause the device to be bulky and difficult to retrieve. By using a bioresorbable material, the implant can be eventually be replaced by native fibrous tissue and completely occlude the defect. (20111219)(Z02056)
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The University of Minnesota has developed a method to produce glycerin-free biodiesel using a proprietary, genetically engineered enzyme. This method reduces the costs and improves the purity of biodiesel production. The method shows great promise to use cellulosic feedstock. (Z07163)
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Biotransformation with improved redox balance uses renewable carbon feed stocks to create a myriad of products, including chemicals, fuels, additives, and pharmaceutical compounds. The technology reduces the redox imbalance without diverting carbon to side products which improves the overall efficiency. The technology doesn’t require expensive co-factors which reduces overall cost. This technology is an alternative platform to traditional industrial microbial fermentation, which is currently used by a wide range of companies making a variety of products (fuels, specialty chemicals, pharmaceutical compounds, vitamins, enzymes, amino acids, and organic acids). (2012-01-31) (20100174)
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New molecules, that are analogs of HA 14-1, have been developed and target Bcl-2 as a potential cancer treatment. HA 14-1 is a qualified antagonist against anti-apoptotic Bcl-2 which causes resistance to cancer treatment in cancer cells. One of the analogs, sHA 14-1, is insensitive to the drug resistance induced by anti-apoptotic Bcl-2 proteins. It also synergizes the anti-cancer activities of both intrinsic and extrinsic apoptotic stimuli, increasing the potential of sHA 14-1 in cancer therapy. Use of sHA 14-1 can sensitize tumors to cancer treatments which results in lower effective dosages and lower harmful side effects of conventional cancer treatments. (Z07120)
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A method to inhibit ornithine decarboxylase that is suitable for use as a pharmaceutical for the treatment of cancer has been developed. The compound has been shown to be effective at ornithine decarboxylase inhibition potentially without the hearing loss associated with eflornithine. This invention provides a method for treating cancer as well as a method for inhibiting initial cancer development. (2013-01-09) (20110052)
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The protein Annexin II can work through a mechanism to boost immunotherapy treatments. Annexin II possesses several attributes which makes it desirable as a cancer vaccine adjuvant, most importantly it selectively increases the shuttling of exogenous antigen to the MHC I pathway, a key antigen-presenting process associated with tumor killing. (2012-08-02) (20100242)
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A cancer vaccine composed of CpG and glioma cell lysate has the ability to treat and cure drug resistant glioblastoma tumors. Glioma tumors are lethal and carry a very short survival time. This new cancer vaccine elicits an anti-tumor immune response to kill these brain tumors. This vaccine has doubled the median survival in rat models and 50% of rats treated with this vaccine showed long term survival. (Z07013)
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Canine cell lines include melanoma, hemangiosarcoma and osteosarcoma cell lines and tissue samples for research. (2012-05-03) (20110168)
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A planting mixture of switchgrasses and legumes has been shown to sequester carbon at high levels on degraded or marginal lands. This mixture can be used to produce a carbon-negative biofuel or produce carbon offsets which can be sold under the Kyoto protocol or Chicago Climate Exchange. (2012-02-22) (Z08031)
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Immunotoxins are important treatments of drug resistant carcinomas, cancerous tumors, and glioblastomas. Immunotoxins are able to target and kill tumor cells which are not responsive to chemotherapy treatments. By tuning immunotoxins to recognize certain cytokine receptors expressed on the surface of carcinoma cells, the effectiveness of these treatments can be increased greatly and specific cancer types can be targeted. (Z07098)
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Precise localization of the source of heart anomalies, such as ventricular tachycardia, arrhythmia, atrial fibrillation, and atrial flutter, determines the effectiveness of treatment. Testing heart electrical activity and repolarization is performed with either a non-invasive electrode jacket or the more standard catheter-based approach. The heart electrical activity algorithm creates a realistic 3-dimensional volumetric image of the electrophysiology of the myocardium and endocardium. This algorithm guides cardiac ablation of the electrically disruptive tissue and improve clinical outcome over current treatments. (Z06090)
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The ventricular assist device with automatic optimization of parameters provides real-time monitoring for congestive heart failure patients. Heart disease accounts for nearly 25% of all deaths in the United States each year. With over 600,000 new cases each year, the advancement of treatment options is crucial. A need exists for VADs that can detect changes in cardiovascular function and optimize performance accordingly or alert health care professionals if external intervention is required. (2012-10-22) (20120320)
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A biological synthesis of carotenoids results in higher concentrations and fewer impurities than plant based extraction and may be less expensive than chemical synthesis. Furthermore, biosynthesis results in unique carotenoids that are not found in nature which could have far reaching implications in the food colorant or nutraceutical industry. (Z05100)
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A method has been developed that utilizes cryopreservative agents for improving the survivability of hematopoietic cells when frozen. Using a balanced electrolyte solution with an arabinogalactan equivalent, a high-survival rate of hematopoietic cells is maintained. It contains a much smaller concentration of glycerol compared to other methods and does not use DMSO, thus decreasing cell loss due to osmotic stress and DMSO toxicity. This technique will increase effectiveness of cell therapeutics by increasing cell viability following cryopreservation. Overall, this cell cryopreservation method will enhance lymphocyte treatments for tumors, especially following bone marrow transplants, as well as treatments for viral infections. (2012-12-13) (98119)
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Robust microbes capable of efficiently producing cellulosic ethanol and able to withstand the toxic byproducts of cellulose hydrolysis processes have been developed. A major challenge in cellulosic ethanol production is that the sugar feedstocks that microbes require to produce ethanol by fermentation are often created in the same locations as toxic byproducts of the sugar-creation process itself. (Z07117)
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Magnetic resonance software for researchers is available from the Center for Magnetic Resonance Research at the University of Minesota. (20120725) (CMRR)
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Surgical simulators for physician training are produced and adapted by the Center for Research in Education and Simulation Technologies (CREST). Driven by Dr. Rob Sweet, CREST Lab focuses research and innovation on solving real issues and expanding the use of surgical simulation in physician training. (2012-08-30) (20110220)
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The creation of nanomaterials and complex proteins by self-assembly chemical synthesis of multivalent proteins allows for chemical control over the process to engineer specific nanomaterials and complex protein structures. This has a wide range of applications including the self-assembly of designed multivalent antibodies with therapeutic and diagnostic utility, drug delivery molecules, and self-assembly of enzymes. (Z05097)
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The bioreactor creates “designer organisms” that utilize renewable resources to produce cellulosic fuels, cellulosic chemicals, and cellulosic ethanol. Microbe growing bioreactors are vital systems in the development of these organisms that must be able to consume a variety of feedstocks, survive the toxic by-products of the production process, and must withstand a variety of temperatures and conditions. Such robust organisms are a major focus of biofuel companies that are currently investing significant amounts of money into biotechnology research and the development of these organisms. (2012-05-07)(Z02025)
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The Reverse Plug Cytometer combines the positive features of traditional flow cytometers, laser scanning, and imaging cytometers but specifically, enables single cell tracking of large numbers of cells. (2012-05-03) (Z07102)
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A method, using, co-cultured microbes, Synechococcus and Shewanella, to produce long-chain hydrocarbons directly from sunlight and water, eliminates the costs and challenges associated with obtaining, transporting, and processing cellulosic feedstocks to make vehicle fuels. The technology does not require large amounts of dedicated agricultural land which eliminates the competition with existing food sources. The research has been funded through a DOE ARPA-E grant. (20100084)
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The competing endogenous RNA database encompasses all potential ceRNA and allows users to access ceRNA specifics with a list which they can scroll through. The database provides mRNA and miRNA information and can help lower costs of drug discovery and development. (2012-10-17) (20120302)
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Online learning modules for teaching complementary therapies and holistic medicine are provide reputable resources and information in the field of alternative complementary medicine, which has continued to gain exposure and popularity. The content of each online learning module meets competencies required for accredited medical, nursing, and pharmacy courses. (2012-06-07)
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Compounds with a unique mechanism of action that involves boosting a key DNA repair enzyme in the skin have been developed. When skin treated with these compounds is exposed to UV light, the epidermis and collagen structure and levels are both maintained. Extensive testing has shown the compounds to prevent DNA damage and maintain youthful looking skin. (2012-06-21) (20110151)
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This surgical training aid improves the quality of training for surgical procedures by providing real-time virtual reality simulations. The technology provides an interactive learning environment with high-fidelity models using real tissue properties with realistic textures. The surgical simulation software applies real tissue properties to a virtual environment allowing students to quickly, effectively, and repetitively simulate a surgery. (Z07108)
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The Minnesota Laboratory for Low-Vision Research at the University of Minnesota has designed a continuous-text reading chart to measure reading acuity, critical print size and reading speed. The charts can be used to measure reading vision for people with normal vision and those with a wide range of vision impairments (“low vision”). The MNREAD Charts are available in both English and Spanish versions and are used by eye care professionals, rehabilitation specialists, and vision researchers. The MNREAD chart extends the capability of eye examinations by measuring the patient’s reading acuity, maximum reading speed, and critical print size, which is the smallest print size that supports the maximum reading speed. MNREAD Charts can be used to prescribe optical corrections for reading, complete low vision assessments, and prescribe magnifiers or other reading aids. (94074)
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A dairy farm application for mobile devices allows for the standardization in which dairy herds are evaluated in regards to cow comfort, animal well-being, biosafety, food safety, nutrition as well as many other factors pertaining to the dairy industry. This streamlined approach using mobile devices allows for a much more efficient and practical method for data collection and sharing that will help to revolutionize the way in which the dairy industry professionals can access critical information. (2012-04-24) (20120138)
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The Digital Pathology Virtual Microscope Slides for Hematology allow medical students and allied health professionals to access hematology microscope slides through the use of an online database for distance learning and enhanced curriculum delivery. This database is the first with a high quality resolution of 83X oil immersion. High resolution images are necessary for the proper examination of blood cells. The Digital Pathology Virtual Microscope Slides are less expensive than replicating, storing, and creating new glass slide sets, and are convenient to access. The development of the virtual microscope database can transform traditional teaching methods by removing the reliance on physical space, equipment, and specimens to a model that is solely dependent upon computer-internet access. The slide sets are a tremendous resource in the instruction of new clinical laboratory scientists for their roles as qualified professionals in the health care industry. (20110025)
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DNA electrophoresis uses microfluidic technology to separate DNA strands which increases the speed at which the separation process takes place with a much higher efficiency. The technology, called Nanofence, is made up of an ordered array of posts that are embedded in the microfluidic chip used in microchip electrophoresis. The posts in the Nanofence technology are placed within the channels on the microfluidic chips. Gaps in between the posts are based on the size of DNA allowing for customized separation conditions for specific needs. (2012-05-31) (20110194)
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A recently developed lupulone compound and pharmaceutically acceptable delivery method have been shown to act in cancer inhibition and bacterial growth inhibition, even those that are resistant to multiple drugs. The compound, hexahydrocolupulone, is highly potent and has a relatively low IC50. The compound likely stops inhibition by interfering with the G1-S phase transition. This compound could be used in constructing a more effective agent for the treatment of multidrug resistant cancer lines and multidrug-resistant bacteria strains. (2012-12-18) (91055)
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Drug resistant tuberculosis treatment using compounds proven to inhibit a vital enzyme in mycobacterium tuberculosis not found in humans and is not required by the host flora. The bacteria that cause TB lose their virulence without the function of this enzyme. Since the target is novel, it is expected to be active against multidrug resistant tuberculosis and extensively drug resistant tuberculosis (MDR and XDR). (2012-05-31) (Z06066)
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A dual-mode ultrasound system for high-intensity focused ultrasound (HIFU) offers temporal resolution on the order of milliseconds. The system is closed-loop and offers real-time intensity modulation based on continuous monitoring of tissue response to the HIFU beam. This method offers improved temporal resolution over MRI-guided procedures, which is expected to improve clinical outcome and reduce treatment time. (20100235)
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An E. coli strain has been genetically engineered that can convert unrefined glycerol to ethanol in a fast and high yield E. coli fermentation process. Glycerol waste (also called glycerin or glycerine) is the major waste product in biodiesel manufacturing processes, and this E. coli strain can efficiently convert this biodiesel waste into ethanol, a type of biofuel. Existing processes utilize E. coli for bacterial fermentation to convert glycerol to ethanol, but at much lower yields and much slower rates. (Z09192)
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For cost effective management of chronic heart disease, implantable devices can be used for early detection of atrial fibrillation and pulmonary edema. With slight changes to hardware and software, current pacemakers and defibrillators could be used for monitoring the stress of the left atrium on a continuous basis. (Z05107)
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Bacterial growth and biofilm formation can be inhibited using a method that generates a low frequency electromagnetic field (EMF) on all surfaces of a nanoparticle-coated medical device. This will help slow the rate of nosocomial infections.
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The enhanced computed tomography scan can recover 3D CT images taken within a limited angular range or limited quality of data. The proposed method significantly reduces undesirable image artifacts and shows robustness to noise. The enhanced CT scan method can reduce the operation and product costs, improve the quality of CT scanner, and ultimately reduce CT radiation risks. (2012-06-20) (Z07020)
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The DNA aptamer that binds specifically to the human protein fractalkine (FKN) is better suited for targeted drug delivery than other technologies such as antibodies. These aptamers have shown to be non-immunogenic and non-toxic in preclinical and clinical tests. Fractalkine is a recently discovered chemokine, and it acts as an adhesion molecule for leukocytes. This feature makes fractalkine a preferred candidate for targeting. (2012-10-11) (20120074)
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Functionalized nanoparticles possess an enzyme capable of digesting fibrin in a tumor’s extracellular matrix. This allows the nanoparticles to deliver anticancer drugs more effectively because their movement is facilitated. (2012-06-07) (20120116)
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A geothermal power generation system has been designed that will allow a power plant to be run from geothermal heat energy and uses carbon dioxide (CO2) gases accumulated from carbon dioxide sequestration. This method is a superior alternative to traditional geothermal power plants because it uses carbon dioxide in place of groundwater as the working fluid. Water is significantly more difficult to heat in low temperature thermal wells and the hydrofracturing required to use water as the working fluid has been linked to earthquakes. This geothermal power generation system could be used in more locations throughout the world, and without the potential of seismic shocks. (Z09126)
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BAC transgenic mouse that expresses GFP when stimulated through the T or B cell antigen receptor has many applications for basic research on the immune system, infectious disease, autoimmune disease, transplantation, vaccination, and immunotherapy for cancer. (2012-05-03) (20110048)
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The giant magnetoresistance (GMR) biomolecule sensing system for drug development and biomedical testing can test large number of samples simultaneously. A system based on this sensor may be able to test up to 1000 nanoparticle tagged biomolecules in 5 minutes. The GMR biomolecule-sensing system has applications in diagnostic centers and laboratories as well as in drug discovery. (2012-10-16) (20110105)
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This technology, a giant magnetoresistive (GMR) chip and nanoparticle system, allows for highly sensitive detection of biomarkers and antigens. The increased sensitivity of this sensor allows the device to test for antigens and biomarkers with high accuracy in very small samples of fluid. The low cost to manufacture makes it more affordable to track the efficacy of therapeutic treatments, diagnose infectious diseases, diagnose chronic diseases at an earlier, more treatable stage, and aid in the development of new immunoassays with detection of biomarker detection at previously undetectable levels. This technology provides a paradigm shift in clinical diagnostics to point-of-care by making tests more accessible and cost effective for clinics, laboratories, and hospitals. (Z09106)
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A graphene based variable capacitor varactor uses the quantum properties of graphene to measure charge. The result is a significant size reduction (around 1000x) compared to MEMS based wireless sensors. The graphene based sensor has significantly higher sensitivity in the detection of charge and a superior quality factor (Q) than alternative charge sensing devices. Since it is passive and does not require an external power source, the device should be low cost and suited to in vivo applications such as radiation dosimetry for accurate external beam radiation therapy and radioactive seeds (brachytherapy) as well applications, such as monitoring blood glucose. (20110133)
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A halogen disinfectant cartridge sterilizes the water and air used in dental procedures by killing bacteria as the water and air is expelled by dental tools. These cartridges use a halogen disinfectant media and a corresponding manifold assembly. The invention is compatible with conventional dental tools. (2012-06-07) (94007)
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The unmanned syringe filtration system for liquids allows researchers to perform other tasks in the lab while solutions are filtered. The liquid filtration system is low cost and fits most syringes. The loaded syringe and filter are placed in the “Gopher Squeeze” which incorporates a pressure knob, replacing the force applied by hand. The researcher only needs to turn the knob to increase the spring tension to keep pressure on the syringe. (2012-11-20) (20130024)
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A recently developed Factor IX variant that has 10-15 times greater activity than wild-type Factor IX proteins is effective with less frequent administration and can be coupled with other technologies to produce even better combination characteristics. (2013-01-22) (20120085)
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Human HINT1, human HINt3 and E. coli HINt (yclF) have been successfully cloned and purified for use in drug discovery. These cell surface binding proteins belong to the histidine triad family and act as prodrugs with anticancer and anti-viral applications. The proteins purified are specifically useful enzymes in discovering prodrugs targeting cancer cells, bacteria, viruses, and fungi. (Z04016)
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Histology Time Online helps students learn anatomy and cell biology through the histology atlas of cells, tissues, and organs organized into nineteen chapters with instructions and self-testing modes. With more than 5,000 images, Histology Time is far ahead of the many other histology packages now available, most of which contain around 1,000 images. (Z01136)
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The Human Brain Anatomy software package, NeuroTime®, helps students study neuroanatomy, learn the central nervous system structures and interpret brain MRI images (magnetic resonance imaging) in an interactive environment. The software includes high quality images of intact and dissected gross specimens of the central nervous system, whole brain sections and brain MRI images. Information is presented in three dimensions to assess the relationship between cross-sections of the specimens. The software has a brain anatomy Quiz Mode for knowledge testing. NeuroTime® offers a convenient, mobile, electronic alternative to specimens that must be kept in liquid, reducing exposure of faculty and students to formalin, a mixture of formaldehyde, methanol, and water, saving their time and eliminating the cost of maintaining a specialized lab facility. (Z01192)
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This biodegradable material is bulk hydrophobic but is hydrophilic at the surface, and is inert to biofouling and cell attachment. This feature is preserved as the polymer degrades generating essentially a renewable inert biosurface. These materials have wide applications such as in the coating of medical devices and other inert surfaces. (2012-11-13) (20120269)
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An ibogaine analog and delivery method have been designed to be used in anti-addiction therapy. The compound can exhibit many of the native beneficial bioactivities of ibogaine without the more harmful effects of ibogaine. (2012-12-18) (95066)
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A wireless glucose sensor provides continuous readout of blood glucose levels when implanted under the skin. This continuous glucose monitor (CGM) uses innovative glucose-sensitive magnetized gel and mechanisms to detect and transmit that are inert to surrounding tissues. The combination of small size, wireless operation, and absence of enzyme-mediated bioelectrochemistry all suggest that the proposed glucose sensor will be a strong alternative to CGM products that are commercially available or under research and development. (2012-11-05) (20120130)
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Medication adherence can be improved by linking a portable and inexpensive pill box with a technological device (e.g. phone, computer, television,) via a tethered or wireless connection to provide increasingly insistent reminders to the patient, and may alert a health care provider. Reminders may include phone calls from health care providers or appeals from family, and may deactivate the technological device until medication adherence resumes. (2012-10-30) (20120243)
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Pulmonary edema, a leading complication of heart failure, can be monitored by measuring the impedance of the lungs from the leads of an implanted cardiac pacemaker, CRT-D or ICD. The impedance between the leads and the pacemaker itself provides a measurement of the extent of pulmonary edema in the patient. A new method for measuring this by placing two additional voltage pickups along the pacemaker, CRT-D or ICD leads increases the sensitivity of the measurement by three to four fold. (Z08220)
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The quality of NMR spectroscopy can be improved by acquiring more half spin-echo data and using an iterative numerical method to reconstruct missing data points of the corresponding full symmetrical echo data, allowing for a better-quality NMR spectrum with sharper peaks. The technique is advantageous at higher fields and has applications in NMR.
(20111214) (Z00135)
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A mouse model of human plasma cell neoplasms (PCN) that may be useful to study the mechanism of the Myc/Bcl-XL collaboration and to design new approaches for treatment and prevention of human PCNs. (2012-05-30) (Z02078)
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The transcription activator constitutes a molecular device that activates gene expression upon induction via a synthetic protein molecule and its complementary DNA promoter sequence. With this molecular device, scienstists and engineers can deliberately and precisely turn on and off the production of proteins in bacteria. (2012-05-08) (20100153)
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The interactive inferior vena cava medical model mimics human anatomical structures and is available for surgery training. This model simulates the inferior vena cava by mimicking the look and feel of the entire structure, as it would be within the human body and is a training tool for vessel repair and injury management. The model is reconstructed using anatomical structures as mold templates and, using a data base of tissue behavior algorithms, the organs, vessels and tissue layers produced mimic real human structures, providing a much more realistic teaching tool than a traditional anatomical manikin. (2012-09-01) (IVC20110220)
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Influenza infections such as triple reassortant influenza A viruses (IAV) of swine are beginning to emerge as zoonotic strains in swine-herds. Recently discovered DNA aptamers are high precision influenza A-specific aptamers and may allow for rapid detection and typing of viruses. (2012-11-20) (20130017)
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A method using polynucleotide analogues selectively represses the specific genes in the zebrafish, making it possible to ascribe a particular biological function to a known nucleic acid sequence. (2012-12-20) (Z00220)
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The genetic testing system on a chip includes a miniaturized thermal cycling device and an integrated, unitary microchip based detection device with microfluidic controls and on chip electronics. (2012-12-20) (96102)
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An iPad app for anatomy browsing helps doctors communicate more effectively with patients.
Patients gain a better understanding of their ailments through 3D, interactive models of the male and female anatomy. Users are able to play animations of specific procedures while still being able to interact with the 3D model. All of these features aid in patient/doctor relationship and are available on the iPad for doctors to use when meeting with patients. Enhanced communication is achieved by giving patients the ability to better understand the effects of a disease which then leads to more informed consent decisions prior to surgery and diagnosis. (2012-07-12) (20120008)
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Researchers would use the iron deficiency mouse model to understand the fundamental biology behind iron deficiency's effects on the brain. (2012-05-03) (Z09100)
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The Irregualr Autograft Bone Dowel provides a biologic alternative to the artificial implants used in sacroiliac fusion surgery and can eliminate abnormal joint motion and minimize low back pain. Current fixation methods rely on artificial implants which lead to a long, painful recovery. The technology is a tool to remove a core of bone tissue, compact it, and reinsert it into the evacuated space for use as a biocompatible bone dowel in sacroiliac joint fixation surgery. (2013-04-02) (20130192)
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An efficient software based tool uses verbal fluency to detect Alzheimer’s disease, dementia and learning disabilities. The technology uses language analysis algorithms on recorded audio files of patients speaking to quantify a variety of speech characteristics known to be altered in states of cognitive dysfunction. (2013-01-10) (20120188)
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Multivariate Visualization for Surgical Training and Skills is an add-on to surgical simulations system that displays new quantitative surgical performance data as it is collected from surgical instruments. This software was specifically designed to improve training for laparoscopic surgery, which are more difficult to train for because of the layer of indirection between the surgeon and the surgical tools. The software system visually displays the quantitative data--by shading the areas where too much pressure was applied in a different color--allowing surgeons to analyze and evaluate their operational skills. (20120090) (2012-09-05)
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A gene region from Lawsonia intracellularis has been identified that contains highly expressed potential antigens for diagnostic or vaccine development for livestock. Lawsonia intracellularis is a fastidious intracellular bacterium that causes an intestinal hyperplasic disease characterized by thickening of the mucosa of the intestine due to enterocyte proliferation. (2013-06-07) (20120131)
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Analogues of parthenolide (PTL) have proven, in vitro, to be nearly twice as cytotoxic as PTL. Not only are these analogues more cytotoxic than PTL, they are also much more water soluble, enhancing their potential for pharmaceutical application. The analogues attack both cancer stem cells and bulk cancer cells, these leukemia treatments have a smaller chance of relapse. (2012-12-17) (20110055)
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Researchers at the University of Minnesota have developed a method for the rapid creation of liquid hydrocarbon fuel directly from biomass feedstock that does not require expensive hydrogen inputs. The entire process is low-pressure which alleviates the need for high-cost, high-pressure reaction vessels. This method allows for the fast conversion of biomass with alkane and/or alcohol co-reactants over zeolite multifunctional catalyst films and bypasses several expensive, slow, or low yield processing steps usually required for the biofuel. (20090008)
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Researchers at the University of Minnesota have identified an at-risk haplotype in people with systemic lupus erythmatosus. Lupus is an autoimmune disease in which the immune system attacks the patient’s body. The identification of this haplotype will help researchers to investigate the cause of the disease and search for a cure. The haplotype has been shown to correlate with over expression of IRF-5. Drugs targeting this may prevent the frequent flare ups associated with lupus. (Z06083)
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A pulse sequence, data acquisition and post-processing technique have been developed and implemented in software to obtain magnetization transfer (MT) images with dramatically improved sensitivity and specificity. The method uses two consecutive pulses (conventional and inversion), which produces improved imaging of white matter in the brain and cartilage with decreased RF heating of tissue. The technology enhances the ability to diagnose and monitor demyelinating neuropathies, such as multiple sclerosis. (2012-01-25) (20100117)
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Proximity-based Intensity Normalization (PIN) software offers improved evaluation of mass spectrometry data to identify molecules of biological interest. It dramatically improves the accuracy in the evaluation of mass spectrometry data, making it useful not only to identify proteins, but also for metabolite and peptide identification. (20121211) (20120293)
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The handheld device measures the soft tissue tension during orthopedic surgery using three separate sensors that can move independently. The device measures tissue tension and displays data to notify the surgeon. The device is placed against the tissue with minimal pressure so as not to damage the tissue. The real time information provided by this device can be used to evaluate and enhance surgical outcomes in various procedures. This device may enhance outcomes for surgeries such as total knee replacements, ACL repairs, and shoulder stabilization procedures. (2012-12-14) (20120134)
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Three dimensional accurate human anatomical structure holograms can be used as informative decoration for medical offices and for patient education. The patented hologram technology consists of a thin plastic sheet that can be illuminated by an appropriate light source to reveal a full 3D image which appears to float above the surface. The medical hologram can bring to life complex structures in beautiful detail in either full color or monochrome green. The holograms are both decorative and informative, as physicians can use the detailed images to convey complex information to patients. (2012-09-03) (Hol20110220)
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